美国专利US20010001835A1 Vascular embolization with an expansible implant

专利PDF首页>>美国专利

专利附录

专利说明

权利要求

类似技术

同族专利

引用文献

法律状态

优先权

专利摘要:
A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
公开号:US20010001835A1
申请号:US09/730,071
申请日:2000-12-05
公开日:2001-05-24
发明作者:George Greene；Robert Rosenbluth；Brian Cox
申请人:Greene George R.；Rosenbluth Robert F.；Cox Brian J.；
IPC主号:A61L31-146

专利说明:
[0001] Not Applicable [0001] FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
[0002] Not applicable [0002] BACKGROUND OF THE INVENTION
[0003] The present invention relates to the field of methods and devices for the embolization of vascular aneurysms and similar vascular abnormalities. More specifically, the present invention relates to (a) an expansible vascular implant that is inserted into a vascular site such as an aneurysm to create an embolism therein; (b) a method of making the expansible implant; and (c) a method and an apparatus for embolizing a vascular site using the implant. [0003]
[0004] The embolization of blood vessels is desired in a number of clinical situations. For example, vascular embolization has been used to control vascular bleeding, to occlude the blood supply to tumors, and to occlude vascular aneurysms, particularly intracranial aneurysms. In recent years, vascular embolization for the treatment of aneurysms has received much attention. Several different treatment modalities have been employed in the prior art. U.S. Pat. No. 4,819,637-Dormandy, Jr. et al., for example, describes a vascular embolization system that employs a detachable balloon delivered to the aneurysm site by an intravascular catheter. The balloon is carried into the aneurysm at the tip of the catheter, and it is inflated inside the aneurysm with a solidifying fluid (typically a polymerizable resin or gel) to occlude the aneurysm. The balloon is then detached from the catheter by gentle traction on the catheter. While the balloon-type embolization device can provide an effective occlusion of many types of aneurysms, it is difficult to retrieve or move after the solidifying fluid sets, and it is difficult to visualize unless it is filled with a contrast material. Furthermore, there are risks of balloon rupture during inflation and of premature detachment of the balloon from the catheter. [0004]
[0005] Another approach is the direct injection of a liquid polymer embolic agent into the vascular site to be occluded. One type of liquid polymer used in the direct injection technique is a rapidly polymerizing liquid, such as a cyanoacrylate resin, particularly isobutyl cyanoacrylate, that is delivered to the target site as a liquid, and then is polymerized in situ. Alternatively, a liquid polymer that is precipitated at the target site from a carrier solution has been used. An example of this type of embolic agent is a cellulose acetate polymer mixed with bismuth trioxide and dissolved in dimethyl sulfoxide (DMSO). Another type is ethylene glycol copolymer dissolved in DMSO. On contact with blood, the DMSO diffuses out, and the polymer precipitates out and rapidly hardens into an embolic mass that conforms to the shape of the aneurysm. Other examples of materials used in this “direct injection” method are disclosed in the following U.S. Pat. Nos.: 4,551,132-Pásztor et al.; 4,795,741-Leshchiner et al.; 5,525,334-Ito et al.; and 5,580,568-Greff et al. [0005]
[0006] The direct injection of liquid polymer embolic agents has proven difficult in practice. For example, migration of the polymeric material from the aneurysm and into the adjacent blood vessel has presented a problem. In addition, visualization of the embolization material requires that a contrasting agent be mixed with it, and selecting embolization materials and contrasting agents that are mutually compatible may result in performance compromises that are less than optimal. Furthermore, precise control of the deployment of the polymeric embolization material is difficult, leading to the risk of improper placement and/or premature solidification of the material. Moreover, once the embolization material is deployed and solidified, it is difficult to move or retrieve. [0006]
[0007] Another approach that has shown promise is the use of thrombogenic microcoils. These microcoils may be made of a biocompatible metal alloy (typically platinum and tungsten) or a suitable polymer. If made of metal, the coil may be provided with Dacron fibers to increase thrombogenicity. The coil is deployed through a microcatheter to the vascular site. Examples of microcoils are disclosed in the following U.S. Pat. Nos.: 4,994,069-Ritchart et al.; 5,133,731-Butler et al.; 5,226,911-Chee et al.; 5,312,415-Palermo; 5,382,259-Phelps et al.; 5,382,260-Dormandy, Jr. et al.; 5,476,472-Dormandy, Jr. et al.; 5,578,074-Mirigian; 5,582,619-Ken; 5,624,461-Mariant; 5,645,558-Horton; 5,658,308-Snyder; and 5,718,711-Berenstein et al. [0007]
[0008] The microcoil approach has met with some success in treating small aneurysms with narrow necks, but the coil must be tightly packed into the aneurysm to avoid shifting that can lead to recanalization. Microcoils have been less successful in the treatment of larger aneurysms, especially those with relatively wide necks. A disadvantage of microcoils is that they are not easily retrievable; if a coil migrates out of the aneurysm, a second procedure to retrieve it and move it back into place is necessary. Furthermore, complete packing of an aneurysm using microcoils can be difficult to achieve in practice. [0008]
[0009] A specific type of microcoil that has achieved a measure of success is the Guglielmi Detachable Coil (“GDC”). The GDC employs a platinum wire coil fixed to a stainless steel guidewire by a solder connection. After the coil is placed inside an aneurysm, an electrical current is applied to the guidewire, which heats sufficiently to melt the solder junction, thereby detaching the coil from the guidewire. The application of the current also creates a positive electrical charge on the coil, which attracts negatively-charged blood cells, platelets, and fibrinogen, thereby increasing the thrombogenicity of the coil. Several coils of different diameters and lengths can be packed into an aneurysm until the aneurysm is completely filled. The coils thus create and hold a thrombus within the aneurysm, inhibiting its displacement and its fragmentation. [0009]
[0010] The advantages of the GDC procedure are the ability to withdraw and relocate the coil if it migrates from its desired location, and the enhanced ability to promote the formation of a stable thrombus within the aneurysm. Nevertheless, as in conventional microcoil techniques, the successful use of the GDC procedure has been substantially limited to small aneurysms with narrow necks. [0010]
[0011] Still another approach to the embolization of an abnormal vascular site is the injection into the site of a biocompatible hydrogel, such as poly (2-hydroxyethyl methacrylate) (“pHEMA” or “PHEMA”); or a polyvinyl alcohol foam (“PAF”). See, e.g., Horák et al., “Hydrogels in Endovascular Embolization. II. Clinical Use of Spherical Particles”, [0011] Biomaterials, Vol. 7, pp. 467-470 (November, 1986); Rao et al., “Hydrolysed Microspheres from Cross-Linked Polymethyl Methacrylate”, J. Neuroradiol., Vol. 18, pp. 61-69 (1991); Latchaw et al., “Polyvinyl Foam Embolization of Vascular and Neoplastic Lesions of the Head, Neck, and Spine”, Radiology, Vol. 131, pp. 669-679 (June, 1979). These materials are delivered as microparticles in a carrier fluid that is injected into the vascular site, a process that has proven difficult to control.
[0012] A further development has been the formulation of the hydrogel materials into a preformed implant or plug that is installed in the vascular site by means such as a microcatheter. See, e.g., U.S. Pat. Nos. 5,258,042-Mehta and 5,456,693-Conston et al. These types of plugs or implants are primarily designed for obstructing blood flow through a tubular vessel or the neck of an aneurysm, and they are not easily adapted for precise implantation within a sack-shaped vascular structure, such as an aneurysm, so as to fill substantially the entire volume of the structure. [0012]
[0013] There has thus been a long-felt, but as yet unsatisfied need for an aneurysm treatment device and method that can substantially fill aneurysms of a large range of sizes, configurations, and neck widths with a thrombogenic medium with a minimal risk of inadvertent aneurysm rupture or blood vessel wall damage. There has been a further need for such a method and device that also allow for the precise locational deployment of the medium, while also minimizing the potential for migration away from the target location. In addition, a method and device meeting these criteria should also be relatively easy to use in a clinical setting. Such ease of use, for example, should preferably include a provision for good visualization of the device during and after deployment in an aneurysm. [0013] SUMMARY OF THE INVENTION
[0014] Broadly, a first aspect of the present invention is a device for occluding a vascular site, such as an aneurysm, comprising a conformal vascular implant, formed of an expansible material, that is compressible from an initial configuration for insertion into the vascular site by means such as a microcatheter while the implant is in a compressed configuration, and that is expansible in situ into an expanded configuration in which it substantially fills the vascular site, thereby to embolize the site, wherein the initial configuration of the implant is a scaled-down model of the vascular site. [0014]
[0015] In a preferred embodiment, the implant is made of a hydrophilic, macroporous, polymeric, hydrogel foam material, in particular a water-swellable foam matrix formed as a macroporous solid comprising a foam stabilizing agent and a polymer or copolymer of a free radical polymerizable hydrophilic olefin monomer cross-linked with up to about 10% by weight of a multiolefin-functional cross-linking agent. The material is modified, or contains additives, to make the implant visible by conventional imaging techniques. [0015]
[0016] Another aspect of the present invention is a method of manufacturing a vascular implant, comprising the steps of: (a) imaging a vascular site by scanning the vascular site to create a digitized scan data set; (b) using the scan data set to create a three-dimensional digitized virtual model of the vascular site; and (c) forming a vascular implant device in the form of a physical model of the vascular site, using the virtual model, the implant being formed of a compressible and expansible biocompatible foam material. In a specific embodiment, the forming step (c) comprises the substeps of: (c)(1) using the virtual model to create a scaled-down, three-dimensional physical mold of the vascular site; and (c)(2) using the mold to create a vascular implant in the form of a scaled-down physical model of the vascular site. [0016]
[0017] In the preferred embodiment of the method of manufacturing the implant, the imaging step is performed with a scanning technique such as computer tomography (commonly called “CT” or “CAT”), magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), or ultrasound. Commercially-available software, typically packaged with and employed by the scanning apparatus, reconstructs the scan data set created by the imaging into the three-dimensional digitized model of the vascular site. The digitized model is then translated, by commercially-available software, into a form that is useable in a commercially available CAD/CAM program to create the scaled-down physical mold by means of stereolithography. A suitable implant material, preferably a macroporous hydrogel foam material, is injected in a liquid or semiliquid state into the mold. Once solidified, the hydrogel foam material is removed from the mold as an implant in the form of a scaled-down physical model of the vascular site. [0017]
[0018] A third aspect of the present invention is a method for embolizing a vascular site, comprising the steps of: (a) passing a microcatheter intravascularly so that its distal end is in a vascular site; (b) providing a vascular implant in the form of a scaled-down physical model of the vascular site, the implant being formed of a compressible and expansible biocompatible foam material; (c) compressing the implant into a compressed configuration dimensioned to pass through a microcatheter; (d) passing the implant, while it is in its compressed configuration, through the microcatheter so that the implant emerges from the distal end of the microcatheter into the vascular site; and (e) expanding the implant in situ substantially to fill the vascular site. [0018]
[0019] The apparatus employed in the embolization method comprises an elongate, flexible deployment element dimensioned to fit axially within an intravascular microcatheter; a filamentous implant retention element disposed axially through the deployment element from its proximal end to its distal end; and an implant device removably attached to the distal end of the retention element. [0019]
[0020] The implant device, in its preferred embodiment, is formed of a moldable, hydrophilically expansible, biocompatible foam material that has an initial configuration in the form of a scaled-down physical model of the vascular site, that is compressible into a compressed configuration that fits within the microcatheter, and that is hydrophilically expansible into an expanded configuration in which it is dimensioned substantially to conform to and fill the vascular site. Alternatively, the implant device may be formed of a non-hydrophilic foam material having an initial configuration that is substantially the same size and shape as the vascular site, and that restores itself to its initial configuration after it is released from its compressed configuration. [0020]
[0021] The retention element is preferably a flexible wire having a distal end configured to releasably engage the implant device while the implant device is in its compressed configuration, thus to retain the implant device within the distal end of the microcatheter while the distal end of the microcatheter is inserted into the vascular site. The wire is movable axially with the deployment element in the distal direction to expose the implant from the distal end of the microcatheter, and is movable proximally with respect to the deployment element to urge the implant device against the distal end of the deployment element, thereby push the implant device off of the wire. Thus released into the vascular site, the implant device expands into an expanded configuration in which it substantially conforms to and fills the vascular site. [0021]
[0022] The present invention provides a number of significant advantages. Specifically, the present invention provides an effective vascular embolization implant that can be deployed within a vascular site with excellent locational control, and with a lower risk of vascular rupture, tissue damage, or migration than with prior art implant devices. Furthermore, the implant device, by being modelled on the actual vascular site in which it is to be implanted, effects a conformal fit within the site that promotes effective embolization, and yet its ability to be delivered to the site in a highly compressed configuration facilitates precise and highly controllable deployment with a microcatheter. In addition, the method of fabricating the implant device, by modeling it on each individual site, allows implant devices to be made that can effectively embolize vascular sites having a wide variety of sizes, configurations, and (in the particular case of aneurysms) neck widths. These and other advantages will be readily appreciated from the detailed description that follows. [0022] BRIEF DESCRIPTION OF THE DRAWINGS
[0023] FIG. 1 is a flow chart showing a method of manufacturing a vascular implant in accordance with a preferred embodiment of the manufacturing method aspect of the present invention; [0023]
[0024] FIG. 2 is a perspective view of a vascular implant in accordance with a preferred embodiment of the vascular implant device aspect of the present invention, showing the implant in its initial configuration; [0024]
[0025] FIG. 3 is an elevational view of the implant of FIG. 2, showing the implant in its compressed configuration; [0025]
[0026] FIG. 4 is a perspective view of the implant of FIG. 2, showing the implant in its expanded configuration; [0026]
[0027] FIG. 5 is a cross-sectional view of an implanting apparatus employed in a method of embolizing a vascular site in accordance with a preferred embodiment of the embolizing method aspect of the present invention; and [0027]
[0028] FIGS. 6 through 10 are semischematic views showing the steps in a method of embolizing a vascular site (specifically, an aneurysm) in accordance with a preferred embodiment of the embolizing method aspect of the present invention. [0028] DETAILED DESCRIPTION OF THE INVENTION The Method of Manufacturing a Vascular Implant
[0029] A first aspect of the present invention is a method of manufacturing a vascular implant device. The steps of a preferred embodiment of the manufacturing method are shown as a sequence of descriptive boxes in the flow chart of FIG. 1. [0029]
[0030] The first step, shown in box [0030] 10 of FIG. 1, is the step of creating an image of a vascular site, such as an aneurysm, in which an embolizing implant is to be installed. This imaging step is performed by scanning the site using any of several conventional imaging techniques, such as computer tomography, magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), or ultrasound.
[0031] The result of the imaging step is a digitized scan data set that is stored in a computer memory, from which the data set is retrieved for operation of the next step: computerized reconstruction of a three-dimensional digitized virtual model of the vascular site (box [0031] 12 of FIG. 1). This step of creating a three-dimensional digital model is typically performed by software designed for this purpose that is packaged with and employed by the imaging apparatus.
[0032] The digitized, three-dimensional virtual model is then translated into a form in which it can be employed in a commercially-available CAD/CAM program (box [0032] 14) which controls a stereolithography process (box 16) to create a mold for forming an implant device. The translation of the virtual model is performed by software that is commercially available, for example, from Cyberform International, Inc., of Richardson, Tex., and from Stratasys, Inc., of Minneapolis, Minn. The mold (not shown) is preferably scaled-down from the dimensions of the vascular site, with a scale of about 1:2 to about 1:6, with about 1:4 being preferred. Alternatively, the mold may be made “life size” (i.e., 1:1); that is, a full-size or nearly full-size replica of the vascular site. The mold is used in the fabrication of a vascular implant device by conventional molding techniques (box 18). The Implant Device
[0033] A vascular implant device [0033] 20, in accordance with the present invention, is shown in FIG. 2 as it appears in its uncompressed or precompressed initial configuration after withdrawal from the mold. Preferably, the implant device 20 is molded directly onto the distal end portion of an elongate, flexible, filamentous retention element, such as a retention wire 22, for purposes to be described below. The retention wire 22 preferably has a distal end that terminates in a knob 24 (FIG. 5) for better retention of the implant device 20 thereon.
[0034] In the preferred embodiment, the implant device [0034] 20 is made of a biocompatible, macroporous, hydrophilic hydrogel foam material, in particular a water-swellable foam matrix formed as a macroporous solid comprising a foam stabilizing agent and a polymer or copolymer of a free radical polymerizable hydrophilic olefin monomer cross-linked with up to about 10% by weight of a multiolefin-functional cross-linking agent. A suitable material of this type is described in U.S. Pat. No. 5,570,585-Park et al., the disclosure of which is incorporated herein by reference. Another suitable material is a porous hydrated polyvinyl alcohol foam (PAF) gel prepared from a polyvinyl alcohol solution in a mixed solvent consisting of water and a water-miscible organic solvent, as described, for example, in U.S. Pat. No. 4,663,358-Hyon et al., the disclosure of which is incorporated herein by reference. Still another suitable material is PHEMA, as discussed in the references cited above. See, e.g., Horak et al., supra, and Rao et al., supra. The foam material preferably has a void ratio of at least about 90%, and its hydrophilic properties are such that it has a water content of at least about 90% when fully hydrated.
[0035] In a preferred embodiment, the implant device [0035] 20, in its initial, precompressed configuration, will have the same configuration as the vascular site, but it will be smaller, by a factor of approximately two to approximately six. The material of the implant device 20, and its initial size, are selected so that the implant device 20 is swellable or expansible to approximately the size of the vascular site, primarily by the hydrophilic absorption of water molecules from blood plasma, and secondarily by the filling of its pores with blood. The result is an expanded configuration for the implant device 20, as shown in FIG. 4, that is large enough substantially to fill the vascular site.
[0036] Alternatively, the implant [0036] 20 device can be molded so that in its initial, precompressed configuration, it is “life size”, i.e., approximately the same size as the vascular site. In this case, the preferred material is a compressible, non-hydrophilic polymeric foam material, such as polyurethane. In actual clinical practice, a non-hydrophilic implant device 20 would advantageously be made slightly smaller than actual life size, to accommodate swelling due to the filling of the pores.
[0037] The foam material of the implant device [0037] 20, whether hydrophilic or non-hydrophilic, is advantageously modified, or contains additives, to make the implant 20 visible by conventional imaging techniques. For example, the foam can be impregnated with a water-insoluble radiopaque material such as barium sulfate, as described by Thanoo et al., “Radiopaque Hydrogel Microspheres”, J. Microencapsulation, Vol. 6, No. 2, pp. 233-244 (1989). Alternatively, the hydrogel monomers can be copolymerized with radiopaque materials, as described in Horák et al., “New Radiopaque PolyHEMA-Based Hydrogel Particles”, J. Biomedical Materials Research, Vol. 34, pp. 183-188 (1997).
[0038] Whatever the material from which the implant device [0038] 20 is made, the implant device 20 must be compressible to a fraction of its initial size, preferably into a substantially cylindrical or lozenge-shaped configuration, as shown in FIG. 3. Compression of the implant device 20 can be performed by squeezing it or crimping it with any suitable fixture or implement (not shown), and then “setting” it in its compressed configuration by heating and/or drying, as is well-known. The purpose for this compression will be explained below in connection with the method of using the implant device 20 to embolize a vascular site. The Method and Apparatus for Embolizing a Vascular Site
[0039] The method of embolizing a vascular site using the implant device [0039] 20 is performed using an implanting apparatus 30, a preferred embodiment of which is shown in FIG. 5. The implanting apparatus 30 comprises the retention element or wire 22, a microcatheter 32, and an elongate, flexible, hollow, tubular element 34 (preferably a coil) that functions as an implant deployment element, as will be described below. With the implant device 20 attached to the distal end of the retention wire 22, the proximal end of the retention wire 22 is inserted into the distal end of the implant deployment element 34 and threaded axially through the implant deployment element 34 until the proximal end of the implant device 20 seats against, or is closely adjacent to, the distal end of the implant deployment element 34. The implant deployment element 34 is dimensioned for passing axially through the microcatheter 32. Thus, the implant deployment element 34, with the implant device 20 extending from its proximal end, may be inserted into the proximal end (not shown) of the microcatheter 32 and passed axially therethrough until the implant device 20 emerges from the distal end of the microcatheter 32, as shown in FIG. 5.
[0040] The implant device [0040] 20, in its compressed configuration, has a maximum outside diameter that is less than the inside diameter of the microcatheter 32, so that the implant device 20 can be passed through the microcatheter 32. The implant device 20 is preferably compressed and “set”, as described above, before it is inserted into the microcatheter 32.
[0041] FIGS. 6 through 10 illustrate the steps employed in the method of embolizing a vascular site [0041] 40 using the implant device 20. The vascular site 40 shown in the drawings is a typical aneurysm, but the invention is not limited to any particular type of vascular site to be embolized.
[0042] First, as shown in FIG. 6, the microcatheter [0042] 32 is threaded intravascularly, by conventional means, until its distal end is situated within the vascular site 40. This threading operation is typically performed by first introducing a catheter guidewire (not shown) along the desired microcatheter path, and then feeding the microcatheter 32 over the catheter guidewire until the microcatheter 32 is positioned substantially as shown in FIG. 6. The catheter guidewire is then removed.
[0043] The implant deployment element [0043] 34, with the implant device 20 extending from its distal end, is then passed through the microcatheter 32, as described above, until the implant device 20 emerges from the distal end of the microcatheter 32 into the vascular site 40, as shown in FIGS. 7 and 8. When inserting the implant device 20 into the microcatheter 32, a biocompatible non-aqueous fluid, such as polyethylene glycol, may be injected into the microcatheter 32 to prevent premature expansion of the implant device 20 due to hydration, and to reduce friction with the interior of the microcatheter 32. The implant device 20 thus being exposed from the microcatheter 32 into the interior of the vascular site 40, the pores of the implant device 20 begin to absorb aqueous fluid from the blood within the vascular site 40 to release its “set”, allowing it to begin assuming its expanded configuration, as shown in FIG. 9. Then, if the implant device 20 is of a hydrophilic material, it continues to expand due to hydrophilic hydration of the implant material, as well as from the filling of its pores with blood. If the implant device 20 is of a non-hydrophilic material, its expansion is due to the latter mechanism only.
[0044] Finally, when the expansion of the implant device [0044] 20 is well underway (and not necessarily when it is completed), the retention wire 22 is pulled proximally with respect to the implant deployment element 34, causing the implant device to be pushed off the end of the installation wire 22 by means of the pressure applied to it by the distal end of the implant deployment element 34. The implant device 20, now free of the implanting apparatus 30, as shown in FIG. 10, may continue to expand until it substantially fills the vascular site 40. The implanting apparatus 30 is then removed, leaving the implant device 20 in place to embolize the vascular site 40.
[0045] While a preferred embodiment of the invention has been described above, a number of variations and modifications may suggest themselves to those skilled in the pertinent arts. For example, instead of custom-fabricating the implant device for each patient, implant devices in a variety of “standard” sizes and shapes may be made, and a particular implant device then selected for a patient based on the imaging of the vascular site. In this case, the fabrication method shown in FIG. 1 would be modified by first creating a three-dimensional digital model for each standardized implant, (box [0045] 12), and then proceeding with the subsequent steps shown in boxes 14, 16, and 18. Imaging (box 10) would be performed as an early step in the embolization procedure, followed by the selection of one of the standardized implant devices. This and other variations and modifications are considered within the spirit and scope of the invention, as described in the claims that follow.

权利要求:
Claims (30)
[1" id="US-20010001835-A1-CLM-00001] 1. A vascular implant device for embolizing a vascular site, the device having a compressed configuration from which it is expansible into an expanded configuration substantially conforming to the shape and size of the vascular site.
[2" id="US-20010001835-A1-CLM-00002] 2. The vascular implant device of
claim 1 , wherein the implant device has an initial configuration in which it is in the form of a scaled down model of the vascular site, and from which it is compressible into the compressed configuration.
[3" id="US-20010001835-A1-CLM-00003] 3. The vascular implant device of
claim 2 , wherein the device is formed of a hydrophilic foam material.
[4" id="US-20010001835-A1-CLM-00004] 4. The vascular implant device of
claim 3 , wherein the foam material is a macroporous hydrogel foam material.
[5" id="US-20010001835-A1-CLM-00005] 5. The vascular implant device of
claim 1 , wherein the implant device is compressible into its compressed configuration from its expanded configuration.
[6" id="US-20010001835-A1-CLM-00006] 6. The vascular implant device of
claim 5 , wherein the device is formed of a substantially non-hydrophilic polymeric foam material.
[7" id="US-20010001835-A1-CLM-00007] 7. The vascular implant device of
claim 1 , wherein the device is radiopaque.
[8" id="US-20010001835-A1-CLM-00008] 8. A method of manufacturing a vascular implant device for embolizing a vascular site, comprising the steps of:
(a) imaging a vascular site by scanning the vascular site to create a digitized scan data set;
(b) creating a three-dimensional digitized virtual model of the vascular site using the scan data set; and
(c) forming a vascular implant device in the configuration of a physical model of the vascular site, using the virtual model, the implant being formed from a compressible foam material.
[9" id="US-20010001835-A1-CLM-00009] 9. The method of
claim 8 , wherein the forming step comprises the steps of:
(c)(1) creating a three-dimensional physical mold of the vascular site using the virtual model; and
(c)(2) molding a vascular implant in the configuration of a physical model of the vascular site.
[10" id="US-20010001835-A1-CLM-00010] 10. The method of
claim 9 , wherein the physical mold created in the step of creating the physical mold is a scaled-down physical mold.
[11" id="US-20010001835-A1-CLM-00011] 11. The method of
claim 10 , wherein the implant molded in the molding step is in the form of a scaled-down physical model of the vascular site.
[12" id="US-20010001835-A1-CLM-00012] 12. The method of
claim 8 , wherein the imaging step is performed by a technique selected from the group consisting of computer tomography, magnetic resonance imaging, magnetic resonance angiography, and ultrasound.
[13" id="US-20010001835-A1-CLM-00013] 13. The method of
claim 8 , wherein the step of creating a virtual model is performed by a computer program.
[14" id="US-20010001835-A1-CLM-00014] 14. The method of
claim 9 , wherein the step of creating the mold is performed by a CAD/CAM program.
[15" id="US-20010001835-A1-CLM-00015] 15. The method of
claim 14 , wherein the step of creating the mold is performed by stereolithography controlled by the CAD/CAM program.
[16" id="US-20010001835-A1-CLM-00016] 16. The method of
claim 11 , wherein the compressible foam material includes a hydrophilically expansible foam material.
[17" id="US-20010001835-A1-CLM-00017] 17. The method of
claim 16 , wherein the foam material includes a macroporous hydrogel foam material.
[18" id="US-20010001835-A1-CLM-00018] 18. The method of
claim 9 , wherein physical mold created in the step of creating a physical mold is a substantially full size replica of the vascular site.
[19" id="US-20010001835-A1-CLM-00019] 19. The method of
claim 18 , wherein the implant molded in the molding step is a substantially full size model of the vascular site.
[20" id="US-20010001835-A1-CLM-00020] 20. The method of
claim 19 , wherein the compressible foam material includes a substantially non-hydrophilic polymeric foam material.
[21" id="US-20010001835-A1-CLM-00021] 21. A method of embolizing a vascular site, comprising the steps of:
(a) providing a vascular implant in the form of a physical model of the vascular site, the implant being formed of a moldable, compressible foam material;
(b) compressing the implant into a compressed configuration;
(c) deploying the implant in a vascular site with a microcatheter, while the implant is in its compressed configuration; and
(d) expanding the implant in situ substantially to fill the vascular site.
[22" id="US-20010001835-A1-CLM-00022] 22. The method of
claim 21 , wherein the implant is in the form of a scaled-down model of the vascular site, and wherein the implant is formed of a hydrophilically-expansible foam material.
[23" id="US-20010001835-A1-CLM-00023] 23. The method of
claim 22 , wherein the expanding step is performed by the hydrophilic absorption of fluid by the implant.
[24" id="US-20010001835-A1-CLM-00024] 24. The method of
claim 21 , wherein the deploying step comprises the steps of:
(c)(1) inserting the distal end of the microcatheter into the vascular site;
(c)(2) passing the implant through the microcatheter, while the implant is in its compressed configuration, until the implant emerges from the distal end thereof into the vascular site; and
(c)(3) releasing the implant, while in its compressed configuration, from the distal end of the microcatheter.
[25" id="US-20010001835-A1-CLM-00025] 25. Apparatus for embolizing a vascular site, comprising:
a microcatheter having a distal end and a proximal end;
a vascular implant device configured as a model of the vascular site and formed of a compressible foam material, the implant device having a compressed configuration dimensioned to pass through the microcatheter from the proximal end thereof and out of the distal end thereof;
a retention element contained within the microcatheter and having a distal end detachably connected to the implant device; and
a deployment element operably associated with the retention element and engageable against the implant device so as to separate the implant device from the retention element when the implant device has emerged from the distal end of the microcatheter.
[26" id="US-20010001835-A1-CLM-00026] 26. The apparatus of
claim 25 , wherein the deployment element is dimensioned to pass axially through the microcatheter from the proximal end to the distal end thereof, the deployment element having a distal end that is engageable against the implant device; and
wherein the retention element is movable with the deployment element when the deployment element is passed through the microcatheter, and is also movable between first and second positions relative to the distal end of the deployment element, whereby the implant device is displaced out of the distal end of the microcatheter when the deployment element is passed through the microcatheter, and whereby the implant device is separated from the retention element when the retention element is moved from the first position to the second position.
[27" id="US-20010001835-A1-CLM-00027] 27. The apparatus of
claim 25 , wherein the implant device is initially configured as a scaled-down model of the vascular site and has an expanded configuration in which its substantially conforms to the vascular site.
[28" id="US-20010001835-A1-CLM-00028] 28. The apparatus of
claim 27 , wherein the implant device is formed of a hydrophilic, macroporous, polymeric foam material.
[29" id="US-20010001835-A1-CLM-00029] 29. The apparatus of
claim 25 , wherein the deployment element comprises an elongate, flexible, tubular element.
[30" id="US-20010001835-A1-CLM-00030] 30. The apparatus of
claim 29 , wherein the retention element comprises an elongate, flexible, filamentous element disposed axially through the tubular element and movable with respect thereto between the first and second positions.

类似技术:

公开号 | 公开日 | 专利标题

US6165193A|2000-12-26|Vascular embolization with an expansible implant

EP2008596B1|2014-07-16|Embolic device

AU2005200324B2|2008-05-29|Filamentous embolic device with expansible elements

US8603128B2|2013-12-10|Filamentous embolization device with expansible elements

同族专利:

公开号 | 公开日

AU4731299A|2000-01-24|

US6500190B2|2002-12-31|

ES2260919T3|2006-11-01|

DE69930385T2|2006-12-07|

AT320220T|2006-04-15|

EP1093346A1|2001-04-25|

US6165193A|2000-12-26|

WO2000001308A1|2000-01-13|

US20030088311A1|2003-05-08|

US20030083737A1|2003-05-01|

DE69930385D1|2006-05-11|

US20090112250A1|2009-04-30|

EP1693009B1|2011-05-11|

CA2335822A1|2000-01-13|

CA2335822C|2007-06-26|

US20070176333A1|2007-08-02|

EP1093346B1|2006-03-15|

US7799047B2|2010-09-21|

EP1693009A3|2007-10-17|

BR9911860A|2001-03-20|

US7201762B2|2007-04-10|

US9034005B2|2015-05-19|

CN101108136A|2008-01-23|

CN100407998C|2008-08-06|

JP2002519134A|2002-07-02|

US7483558B2|2009-01-27|

CN1308507A|2001-08-15|

US7029487B2|2006-04-18|

JP4658321B2|2011-03-23|

EP1693009A2|2006-08-23|

JP2009112830A|2009-05-28|

US20110005062A1|2011-01-13|

AU754493B2|2002-11-21|

引用文献:

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

US20030183962A1|2002-03-29|2003-10-02|Scimed Life Systems, Inc.|Processes for manufacturing polymeric microspheres|

US20030203985A1|2002-04-04|2003-10-30|Scimed Life Systems, Inc., A Minnesota Corporation|Forming a chemically cross-linked particle of a desired shape and diameter|

US20030206864A1|2000-03-06|2003-11-06|Scimed Life Systems, Inc., A Minnesota Corporation|Embolic agents visible under ultrasound|

US20040076582A1|2002-08-30|2004-04-22|Dimatteo Kristian|Agent delivery particle|

US20040101564A1|2002-08-30|2004-05-27|Rioux Robert F.|Embolization|

US20040167482A1|2001-11-20|2004-08-26|Richard Watson|Personally portable vacuum desiccator|

US20040266983A1|2000-08-17|2004-12-30|Reeve Lorraine E|Purified polyoxyalkylene block copolymers|

US20050008610A1|2003-03-24|2005-01-13|Alexander Schwarz|Temporary embolization using inverse thermosensitive polymers|

US20050065484A1|2003-09-10|2005-03-24|Watson Richard L.|Wound healing apparatus with bioabsorbable material and suction tubes|

US20050129775A1|2003-08-29|2005-06-16|Scimed Life Systems, Inc.|Ferromagnetic particles and methods|

US20050196449A1|2004-03-02|2005-09-08|Dicarlo Paul|Embolization|

US20050263916A1|2004-06-01|2005-12-01|Janel Lanphere|Embolization|

US20070078506A1|2004-04-13|2007-04-05|Mccormick Paul|Method and apparatus for decompressing aneurysms|

US20090030117A1|2003-08-08|2009-01-29|Boston Scientific Scimed, Inc.|Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient|

US7727555B2|2005-03-02|2010-06-01|Boston Scientific Scimed, Inc.|Particles|

US20100185226A1|2003-11-06|2010-07-22|Pluromed, Inc.|Internal Clamp for Surgical Procedures|

US7790945B1|2004-04-05|2010-09-07|Kci Licensing, Inc.|Wound dressing with absorption and suction capabilities|

US7858183B2|2005-03-02|2010-12-28|Boston Scientific Scimed, Inc.|Particles|

US7883490B2|2002-10-23|2011-02-08|Boston Scientific Scimed, Inc.|Mixing and delivery of therapeutic compositions|

US7947368B2|2005-12-21|2011-05-24|Boston Scientific Scimed, Inc.|Block copolymer particles|

US7951402B2|2002-08-30|2011-05-31|Boston Scientific Scimed, Inc.|Drug delivery particle|

US7963287B2|2005-04-28|2011-06-21|Boston Scientific Scimed, Inc.|Tissue-treatment methods|

US8007509B2|2005-10-12|2011-08-30|Boston Scientific Scimed, Inc.|Coil assemblies, components and methods|

US8101197B2|2005-12-19|2012-01-24|Stryker Corporation|Forming coils|

US8152839B2|2005-12-19|2012-04-10|Boston Scientific Scimed, Inc.|Embolic coils|

US8173176B2|2004-03-30|2012-05-08|Boston Scientific Scimed, Inc.|Embolization|

US8414927B2|2006-11-03|2013-04-09|Boston Scientific Scimed, Inc.|Cross-linked polymer particles|

US8425550B2|2004-12-01|2013-04-23|Boston Scientific Scimed, Inc.|Embolic coils|

US9283078B2|2012-09-21|2016-03-15|Materialise N.V.|Patient-specific intraluminal implants|

US9358140B1|2009-11-18|2016-06-07|Aneuclose Llc|Stent with outer member to embolize an aneurysm|

US9463426B2|2005-06-24|2016-10-11|Boston Scientific Scimed, Inc.|Methods and systems for coating particles|

US10028747B2|2008-05-01|2018-07-24|Aneuclose Llc|Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm|

US10433988B2|2006-02-22|2019-10-08|Covidien Lp|Stents having radiopaque mesh|

US10433853B2|2014-04-18|2019-10-08|Covidien Lp|Embolic medical devices|

US10478195B2|2016-08-04|2019-11-19|Covidien Lp|Devices, systems, and methods for the treatment of vascular defects|

US10478194B2|2015-09-23|2019-11-19|Covidien Lp|Occlusive devices|

US10499939B2|2013-11-13|2019-12-10|Covidien Lp|Galvanically assisted attachment of medical devices to thrombus|

US10548748B2|2009-06-23|2020-02-04|Covidien Lp|Procedures for vascular occlusion|

US10576099B2|2016-10-21|2020-03-03|Covidien Lp|Injectable scaffold for treatment of intracranial aneurysms and related technology|

US10610389B2|2008-05-13|2020-04-07|Covidien Lp|Braid implant delivery systems|

US10617427B2|2010-09-18|2020-04-14|Covidien Lp|Devices and methods for the treatment of vascular defects|

US10624772B2|2011-11-04|2020-04-21|Covidien Lp|Protuberant aneurysm bridging device deployment method|

US10675036B2|2017-08-22|2020-06-09|Covidien Lp|Devices, systems, and methods for the treatment of vascular defects|

US10675037B2|2010-09-18|2020-06-09|Covidien Lp|Devices and methods for the treatment of vascular defects|

US10716573B2|2008-05-01|2020-07-21|Aneuclose|Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm|

US10722255B2|2008-12-23|2020-07-28|Covidien Lp|Systems and methods for removing obstructive matter from body lumens and treating vascular defects|

US10736758B2|2013-03-15|2020-08-11|Covidien|Occlusive device|

US10743882B2|2013-03-15|2020-08-18|Covidien Lp|Delivery and detachment mechanisms for vascular implants|

US10765542B2|2004-05-25|2020-09-08|Covidien Lp|Methods and apparatus for luminal stenting|

US10806609B2|2004-05-25|2020-10-20|Covidien Lp|Vascular stenting for aneurysms|

US10806611B2|2010-12-06|2020-10-20|Covidien Lp|Vascular remodeling device|

US10828039B2|2016-06-27|2020-11-10|Covidien Lp|Electrolytic detachment for implantable devices|

US10828182B2|2011-09-29|2020-11-10|Covidien Lp|Vascular remodeling device|

US10828037B2|2016-06-27|2020-11-10|Covidien Lp|Electrolytic detachment with fluid electrical connection|

US10874401B2|2014-08-08|2020-12-29|Covidien Lp|Electrolytic and mechanical detachment for implant delivery systems|

US10893868B2|2012-01-20|2021-01-19|Covidien Lp|Aneurysm treatment coils|

US10893869B2|2016-03-24|2021-01-19|Covidien Lp|Thin wall constructions for vascular flow diversion|

US10905432B2|2018-08-22|2021-02-02|Covidien Lp|Aneurysm treatment coils and associated systems and methods of use|

US10912569B2|2018-08-22|2021-02-09|Covidien Lp|Aneurysm treatment coils and associated systems and methods of use|

US10918389B2|2004-05-25|2021-02-16|Covidien Lp|Flexible vascular occluding device|

US10952878B2|2012-10-31|2021-03-23|Covidien Lp|Methods and systems for increasing a density of a region of a vascular device|

US11045204B2|2011-05-11|2021-06-29|Covidien Lp|Vascular remodeling device|

US11051822B2|2016-06-28|2021-07-06|Covidien Lp|Implant detachment with thermal activation|

US11065136B2|2018-02-08|2021-07-20|Covidien Lp|Vascular expandable devices|

US11065009B2|2018-02-08|2021-07-20|Covidien Lp|Vascular expandable devices|

US11129621B2|2018-12-17|2021-09-28|Covidien Lp|Devices, systems, and methods for the treatment of vascular defects|

US11147563B2|2011-03-25|2021-10-19|Covidien Lp|Vascular remodeling device|CS154391B1|1970-09-10|1974-04-30|||

US4509504A|1978-01-18|1985-04-09|Medline Ab|Occlusion of body channels|

SE419597B|1979-05-04|1981-08-17|Medline Ab|DEVICE FOR TEMPORARY OR PERMANENT CONNECTION OF BODY CHANNELS OR SPACES OF HUMAN AND ANIMALS|

HU184722B|1980-02-18|1984-10-29|Laszlo Lazar|Therapeutically suitable silicone rubber mixture and therapeuticaid|

US4734097A|1981-09-25|1988-03-29|Nippon Oil Company, Ltd.|Medical material of polyvinyl alcohol and process of making|

US4436684B1|1982-06-03|1988-05-31|||

US4506393A|1983-03-29|1985-03-26|Murphy Stephen B|Method of prosthesis design|

US4673539A|1983-06-03|1987-06-16|Minnesota Mining And Manufacturing Company|Process for thermoformed articles|

US4529739A|1984-07-24|1985-07-16|The Dow Chemical Company|Foamed polymeric materials|

US4795741A|1987-05-06|1989-01-03|Biomatrix, Inc.|Compositions for therapeutic percutaneous embolization and the use thereof|

AU3770989A|1988-05-23|1989-12-12|Lynn L. Augspurger|Method and system for making prosthetic device|

US4819637A|1987-09-01|1989-04-11|Interventional Therapeutics Corporation|System for artificial vessel embolization and devices for use therewith|

US4873707A|1987-09-11|1989-10-10|Brigham & Women's Hospital|X-ray tomography phantoms, method and system|

IL84752A|1987-12-08|1991-11-21|Elscint Ltd|Anatomical models and methods for manufacturing such models|

US5007936A|1988-02-18|1991-04-16|Cemax, Inc.|Surgical method for hip joint replacement|

US4994069A|1988-11-02|1991-02-19|Target Therapeutics|Vaso-occlusion coil and method|

US5354290A|1989-05-31|1994-10-11|Kimberly-Clark Corporation|Porous structure of an absorbent polymer|

US5184306A|1989-06-09|1993-02-02|Regents Of The University Of Minnesota|Automated high-precision fabrication of objects of complex and unique geometry|

US5274565A|1990-10-03|1993-12-28|Board Of Regents, The University Of Texas System|Process for making custom joint replacements|

US5133731A|1990-11-09|1992-07-28|Catheter Research, Inc.|Embolus supply system and method|

US5156777A|1991-03-21|1992-10-20|Kaye Alan H|Process for making a prosthetic implant|

US5226911A|1991-10-02|1993-07-13|Target Therapeutics|Vasoocclusion coil with attached fibrous element|

JP3356447B2|1991-10-16|2002-12-16|テルモ株式会社|Vascular lesion embolic material composed of dried polymer gel|

US5258042A|1991-12-16|1993-11-02|Henry Ford Health System|Intravascular hydrogel implant|

DK0625070T3|1991-12-20|1999-02-22|Allied Signal Inc|Low density materials having high surface area and articles formed therefrom for use in recycling|

US5413560A|1992-03-30|1995-05-09|Pameda N.V.|Method of rapid catheter exchange|

DE4213597A1|1992-04-24|1993-10-28|Klaus Draenert|Femoral prosthesis component to be anchored with bone cement and process for its production|

US5365996A|1992-06-10|1994-11-22|Amei Technologies Inc.|Method and apparatus for making customized fixation devices|

AU4926193A|1992-09-21|1994-04-12|Vitaphore Corporation|Embolization plugs for blood vessels|

US5312415A|1992-09-22|1994-05-17|Target Therapeutics, Inc.|Assembly for placement of embolic coils using frictional placement|

US5382259A|1992-10-26|1995-01-17|Target Therapeutics, Inc.|Vasoocclusion coil with attached tubular woven or braided fibrous covering|

US5382260A|1992-10-30|1995-01-17|Interventional Therapeutics Corp.|Embolization device and apparatus including an introducer cartridge and method for delivering the same|

US5350397A|1992-11-13|1994-09-27|Target Therapeutics, Inc.|Axially detachable embolic coil assembly|

US5690666A|1992-11-18|1997-11-25|Target Therapeutics, Inc.|Ultrasoft embolism coils and process for using them|

US5360446A|1992-12-18|1994-11-01|Zimmer, Inc.|Interactive prosthesis design system for implantable prosthesis|

US5320639A|1993-03-12|1994-06-14|Meadox Medicals, Inc.|Vascular plug delivery system|

WO1995007509A1|1993-09-10|1995-03-16|The University Of Queensland|Stereolithographic anatomical modelling process|

US5795331A|1994-01-24|1998-08-18|Micro Therapeutics, Inc.|Balloon catheter for occluding aneurysms of branch vessels|

US5460621A|1994-03-04|1995-10-24|Merocel Corporation|Composite tissue displacement sponge|

US5573994A|1994-05-13|1996-11-12|University Of Cincinnati|Superabsorbent foams, and method for producing the same|

JP2535785B2|1994-06-03|1996-09-18|工業技術院長|Vascular embolic agent|

CA2194671A1|1994-07-08|1996-01-25|Ev3 Inc.|Method of forming medical devices; intravascular occlusion devices|

US5578074A|1994-12-22|1996-11-26|Target Therapeutics, Inc.|Implant delivery method and assembly|

US5814062A|1994-12-22|1998-09-29|Target Therapeutics, Inc.|Implant delivery assembly with expandable coupling/decoupling mechanism|

US5698213A|1995-03-06|1997-12-16|Ethicon, Inc.|Hydrogels of absorbable polyoxaesters|

US5750585A|1995-04-04|1998-05-12|Purdue Research Foundation|Super absorbent hydrogel foams|

US5645558A|1995-04-20|1997-07-08|Medical University Of South Carolina|Anatomically shaped vasoocclusive device and method of making the same|

US5911731A|1995-04-20|1999-06-15|Target Therapeutics, Inc.|Anatomically shaped vasoocclusive devices|

US5624461A|1995-06-06|1997-04-29|Target Therapeutics, Inc.|Three dimensional in-filling vaso-occlusive coils|

US5582619A|1995-06-30|1996-12-10|Target Therapeutics, Inc.|Stretch resistant vaso-occlusive coils|

US7197170B2|2003-11-10|2007-03-27|M2S, Inc.|Anatomical visualization and measurement system|

US5580568A|1995-07-27|1996-12-03|Micro Therapeutics, Inc.|Cellulose diacetate compositions for use in embolizing blood vessels|

US5658308A|1995-12-04|1997-08-19|Target Therapeutics, Inc.|Bioactive occlusion coil|

US5752974A|1995-12-18|1998-05-19|Collagen Corporation|Injectable or implantable biomaterials for filling or blocking lumens and voids of the body|

US5825908A|1995-12-29|1998-10-20|Medical Media Systems|Anatomical visualization and measurement system|

ZA978537B|1996-09-23|1998-05-12|Focal Inc|Polymerizable biodegradable polymers including carbonate or dioxanone linkages.|

US5762315A|1996-04-10|1998-06-09|Fisher Controls International, Inc.|Valve actuator with pliable pressure conversion device|

US6096034A|1996-07-26|2000-08-01|Target Therapeutics, Inc.|Aneurysm closure device assembly|

US5823198A|1996-07-31|1998-10-20|Micro Therapeutics, Inc.|Method and apparatus for intravasculer embolization|

US6066325A|1996-08-27|2000-05-23|Fusion Medical Technologies, Inc.|Fragmented polymeric compositions and methods for their use|

US5762125A|1996-09-30|1998-06-09|Johnson & Johnson Professional, Inc.|Custom bioimplantable article|

US5863551A|1996-10-16|1999-01-26|Organogel Canada Ltee|Implantable polymer hydrogel for therapeutic uses|

US5672634A|1996-12-23|1997-09-30|Isp Investments Inc.|Crosslinked PVP-I2 foam product|

US6063070A|1997-08-05|2000-05-16|Target Therapeutics, Inc.|Detachable aneurysm neck bridge |

US5916235A|1997-08-13|1999-06-29|The Regents Of The University Of California|Apparatus and method for the use of detachable coils in vascular aneurysms and body cavities|

US6316522B1|1997-08-18|2001-11-13|Scimed Life Systems, Inc.|Bioresorbable hydrogel compositions for implantable prostheses|

CA2307764A1|1997-11-07|1999-05-20|Salviac Limited|Implantable occluder devices for medical use|

EP1071491A4|1998-03-30|2004-10-20|Univ Virginia|Flow arrest, double balloon technique for occluding aneurysms or blood vessels|

US6015424A|1998-04-28|2000-01-18|Microvention, Inc.|Apparatus and method for vascular embolization|

US6113629A|1998-05-01|2000-09-05|Micrus Corporation|Hydrogel for the therapeutic treatment of aneurysms|

US6463317B1|1998-05-19|2002-10-08|Regents Of The University Of Minnesota|Device and method for the endovascular treatment of aneurysms|

AU745302B2|1998-05-23|2002-03-21|Bieniarz, Andre|Method of treatment for premature rupture of membranes in pregnancy |

AU756080B2|1998-06-04|2003-01-02|New York University|Endovascular thin film devices and methods for treating and preventing stroke|

US5935148A|1998-06-24|1999-08-10|Target Therapeutics, Inc.|Detachable, varying flexibility, aneurysm neck bridge|

US6165193A|1998-07-06|2000-12-26|Microvention, Inc.|Vascular embolization with an expansible implant|

US6605294B2|1998-08-14|2003-08-12|Incept Llc|Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels|

SE514718C2|1999-06-29|2001-04-09|Jan Otto Solem|Apparatus for treating defective closure of the mitral valve apparatus|

US6312421B1|1999-07-23|2001-11-06|Neurovasx, Inc.|Aneurysm embolization material and device|

US6238403B1|1999-10-04|2001-05-29|Microvention, Inc.|Filamentous embolic device with expansible elements|

AU2002359410A1|2001-11-16|2003-06-10|Biocure, Inc.|Methods for initiating in situ formation of hydrogels|US7486811B2|1996-09-16|2009-02-03|The Research Foundation Of State University Of New York|System and method for performing a three-dimensional virtual examination of objects, such as internal organs|

US6146373A|1997-10-17|2000-11-14|Micro Therapeutics, Inc.|Catheter system and method for injection of a liquid embolic composition and a solidification agent|

US6511468B1|1997-10-17|2003-01-28|Micro Therapeutics, Inc.|Device and method for controlling injection of liquid embolic composition|

US6165193A|1998-07-06|2000-12-26|Microvention, Inc.|Vascular embolization with an expansible implant|

FR2784580B1|1998-10-16|2004-06-25|Biosepra Inc|POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME|

US7128073B1|1998-11-06|2006-10-31|Ev3 Endovascular, Inc.|Method and device for left atrial appendage occlusion|

US6231613B1|1998-12-15|2001-05-15|Enteric Medical Technologies, Inc.|Methods for soft tissue augmentation in mammals|

US6379329B1|1999-06-02|2002-04-30|Cordis Neurovascular, Inc.|Detachable balloon embolization device and method|

US6312421B1|1999-07-23|2001-11-06|Neurovasx, Inc.|Aneurysm embolization material and device|

EP2319430B1|2001-05-29|2013-11-13|Microvention, Inc.|Vascular embolization device and method of manufacture|

US6238403B1|1999-10-04|2001-05-29|Microvention, Inc.|Filamentous embolic device with expansible elements|

US6602261B2|1999-10-04|2003-08-05|Microvention, Inc.|Filamentous embolic device with expansile elements|

AU3803201A|2000-02-04|2001-08-14|Univ New York State Res Found|System and method for computer aided treatment planning|

US6712856B1|2000-03-17|2004-03-30|Kinamed, Inc.|Custom replacement device for resurfacing a femur and method of making the same|

DE01918975T1|2000-03-24|2006-04-13|Biosphere Medical, Inc., Rockland|Microspheres for active embolization|

US8313504B2|2000-09-18|2012-11-20|Cordis Corporation|Foam matrix embolization device|

US6723108B1|2000-09-18|2004-04-20|Cordis Neurovascular, Inc|Foam matrix embolization device|

US7029486B2|2000-09-26|2006-04-18|Microvention, Inc.|Microcoil vaso-occlusive device with multi-axis secondary configuration|

US6589265B1|2000-10-31|2003-07-08|Endovascular Technologies, Inc.|Intrasaccular embolic device|

US6547804B2|2000-12-27|2003-04-15|Scimed Life Systems, Inc.|Selectively permeable highly distensible occlusion balloon|

US6878384B2|2001-03-13|2005-04-12|Microvention, Inc.|Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use|

WO2003000480A1|2001-06-22|2003-01-03|The Regents Of The University Of Michigan|Methods of designing and fabricating molds|

WO2003007825A1|2001-07-19|2003-01-30|Atritech, Inc.|Individually customized device for covering the ostium of left atrial appendage|

US8715312B2|2001-07-20|2014-05-06|Microvention, Inc.|Aneurysm treatment device and method of use|

US8252040B2|2001-07-20|2012-08-28|Microvention, Inc.|Aneurysm treatment device and method of use|

US7572288B2|2001-07-20|2009-08-11|Microvention, Inc.|Aneurysm treatment device and method of use|

JP4429589B2|2001-11-15|2010-03-10|コーディス・ニューロバスキュラー・インコーポレイテッド|Aneurysm embolization device using an occluding member|

US20060292206A1|2001-11-26|2006-12-28|Kim Steven W|Devices and methods for treatment of vascular aneurysms|

CN1638703A|2002-01-25|2005-07-13|阿特里泰克公司|Atrial appendage blood filtration systems|

US20030171773A1|2002-03-06|2003-09-11|Carrison Harold F.|Methods for aneurysm repair|

US20030199887A1|2002-04-23|2003-10-23|David Ferrera|Filamentous embolization device and method of use|

US7338511B2|2002-05-24|2008-03-04|Boston Scientific-Scimed, Inc.|Solid embolic material with variable expansion|

US7048719B1|2002-06-07|2006-05-23|Microvention, Inc.|Endovascular catheter resheathing apparatus and related methods|

EP1511522B1|2002-06-12|2011-08-10|Boston Scientific Limited|Bulking agents|

US20040002630A1|2002-06-28|2004-01-01|Wu Steven Zung-Hong|Suction device for surgical applications|

US7248914B2|2002-06-28|2007-07-24|Stereotaxis, Inc.|Method of navigating medical devices in the presence of radiopaque material|

US20040044391A1|2002-08-29|2004-03-04|Stephen Porter|Device for closure of a vascular defect and method of treating the same|

US8246673B2|2002-09-19|2012-08-21|Exstent Limited|External support for a blood vessel|

WO2004026178A2|2002-09-19|2004-04-01|Exstent Limited|External stent|

JP2006521907A|2002-10-23|2006-09-28|ザバイオメリックスコーポレーション|Aneurysm treatment device and method|

ES2660627T3|2003-05-15|2018-03-23|Biomerix Corporation|Crosslinked elastomeric matrices, their manufacture and their use in implantable devices|

US7481821B2|2002-11-12|2009-01-27|Thomas J. Fogarty|Embolization device and a method of using the same|

US20040122349A1|2002-12-20|2004-06-24|Lafontaine Daniel M.|Closure device with textured surface|

US8709038B2|2002-12-20|2014-04-29|Boston Scientific Scimed, Inc.|Puncture hole sealing device|

US20080208160A9|2003-01-10|2008-08-28|Mawad Michel E|Microcatheter including swellable tip|

US20040153025A1|2003-02-03|2004-08-05|Seifert Paul S.|Systems and methods of de-endothelialization|

US20040260382A1|2003-02-12|2004-12-23|Fogarty Thomas J.|Intravascular implants and methods of using the same|

WO2004096152A2|2003-04-24|2004-11-11|Arizona Board Of Regents|In situ gelling self-reactive materials for embolization|

US7942897B2|2003-07-10|2011-05-17|Boston Scientific Scimed, Inc.|System for closing an opening in a body cavity|

US20050015110A1|2003-07-18|2005-01-20|Fogarty Thomas J.|Embolization device and a method of using the same|

US20050119687A1|2003-09-08|2005-06-02|Dacey Ralph G.Jr.|Methods of, and materials for, treating vascular defects with magnetically controllable hydrogels|

US20070135907A1|2003-10-02|2007-06-14|The Regents Of The University Of California|Stent with expandable foam|

US8133256B2|2003-10-02|2012-03-13|Lawrence Livermore National Security, Llc|Shape memory polymer foams for endovascular therapies|

US7901770B2|2003-11-04|2011-03-08|Boston Scientific Scimed, Inc.|Embolic compositions|

EP2260776A1|2003-11-21|2010-12-15|Vnus Medical Technologies, Inc.|Apparatus for treating the carotid artery|

US20070104752A1|2003-12-10|2007-05-10|Lee Jeffrey A|Aneurysm embolization material and device|

US20080109057A1|2003-12-10|2008-05-08|Calabria Marie F|Multiple point detacher system|

CA2490343A1|2003-12-17|2005-06-17|Cordis Neurovascular, Inc.|Activatable bioactive implantable medical device and method of use|

US20050137568A1|2003-12-17|2005-06-23|Jones Donald K.|Activatable bioactive implantable medical device and method of use|

US20050149109A1|2003-12-23|2005-07-07|Wallace Michael P.|Expanding filler coil|

US7763077B2|2003-12-24|2010-07-27|Biomerix Corporation|Repair of spinal annular defects and annulo-nucleoplasty regeneration|

US20050165480A1|2004-01-23|2005-07-28|Maybelle Jordan|Endovascular treatment devices and methods|

US20050228433A1|2004-03-16|2005-10-13|Weenna Bucay-Couto|In situ implant and method of forming same|

US8500751B2|2004-03-31|2013-08-06|Merlin Md Pte Ltd|Medical device|

WO2005094725A1|2004-03-31|2005-10-13|Merlin Md Pte Ltd|A method for treating aneurysms|

US7534221B2|2004-05-24|2009-05-19|The Trustees Of Columbia University In The City Of New York|Devices and methods for protecting against distal embolisms|

CA2595809A1|2004-08-31|2006-03-09|Cook Incorporated|Device for treating an aneurysm|

WO2006032291A1|2004-09-22|2006-03-30|Dendron Gmbh|Micro-spiral implantation device|

AT417552T|2004-09-22|2009-01-15|Dendron Gmbh|MEDICAL IMPLANT|

US20060106406A1|2004-09-27|2006-05-18|Judah Weinberger|Methods and devices for extravascular intervention|

US20060069426A1|2004-09-27|2006-03-30|Weinberger Judah Z|Methods and devices for extravascular intervention|

US7186153B2|2004-10-13|2007-03-06|Carrier Corporation|Side entry terminal pin|

US8771294B2|2004-11-26|2014-07-08|Biomerix Corporation|Aneurysm treatment devices and methods|

US20060116713A1|2004-11-26|2006-06-01|Ivan Sepetka|Aneurysm treatment devices and methods|

EP1843720A1|2004-12-22|2007-10-17|Euromed Consult BT.|Prosthesis for the non-invasive treatment of aneurysms|

US20060178696A1|2005-02-04|2006-08-10|Porter Stephen C|Macroporous materials for use in aneurysms|

JP2009525137A|2006-02-02|2009-07-09|ボストンサイエンティフィックリミテッド|Porous material used in aneurysms|

EP1876965B1|2005-04-29|2018-09-12|Cook Biotech, Inc.|Volumetric grafts for treatment of fistulae and related systems|

US8267985B2|2005-05-25|2012-09-18|Tyco Healthcare Group Lp|System and method for delivering and deploying an occluding device within a vessel|

US8273101B2|2005-05-25|2012-09-25|Tyco Healthcare Group Lp|System and method for delivering and deploying an occluding device within a vessel|

EP1883371B1|2005-05-25|2015-10-07|Covidien LP|System and method for delivering and deploying and occluding device within a vessel|

US20070001346A1|2005-06-30|2007-01-04|Murty Vyakarnam|Active embolization device|

US8057495B2|2005-09-13|2011-11-15|Cook Medical Technologies Llc|Aneurysm occlusion device|

US8163002B2|2005-11-14|2012-04-24|Vascular Devices Llc|Self-sealing vascular graft|

EP1986706B1|2006-01-30|2011-08-17|Biosphere Medical, Inc.|Porous intravascular embolization particles and methods of making them|

EP1986707A2|2006-01-30|2008-11-05|Surgica Corporation|Compressible intravascular embolization particles and related methods and delivery systems|

US7959676B2|2006-02-13|2011-06-14|Lanx, Inc.|Method and apparatus for intervertebral disc support and repair|

US20070208277A1|2006-03-06|2007-09-06|Rioux Robert F|Vessel volume determination for embolization|

CN101448464B|2006-04-17|2011-05-04|微治疗公司|System and method for mechanically positioning intravascular implants|

US8777979B2|2006-04-17|2014-07-15|Covidien Lp|System and method for mechanically positioning intravascular implants|

US7818084B2|2006-06-16|2010-10-19|The Invention Science Fund, I, LLC|Methods and systems for making a blood vessel sleeve|

AU2007285800A1|2006-08-17|2008-02-21|Nfocus Neuromedical, Inc.|Isolation devices for the treatment of aneurysms|

JP2010508910A|2006-11-02|2010-03-25|アール．ショーンパクバズ，|Devices and methods for accessing and treating aneurysms|

DE102006056283A1|2006-11-29|2008-06-05|Biomagnetik Park Gmbh|Occlusion device for closing left heart auricle of patient, has cladding bag provided with fillable opening at its proximal end and partially made of thermoplastic polyurethane, where bag is partially filled with non-degradable plastic|

AU2008226695B2|2007-03-13|2013-05-02|Covidien Lp|An implant, a mandrel, and a method of forming an implant|

JP5249249B2|2007-03-13|2013-07-31|コヴィディエンリミテッドパートナーシップ|Implant including a coil and a stretch resistant member|

CA2680812C|2007-03-15|2017-01-24|Ortho-Space Ltd.|Prosthetic devices and methods for using same|

WO2008124361A2|2007-04-06|2008-10-16|Cook Biotech Incorporated|Fistula plugs having increased column strength and fistula plug delivery apparatuses and methods|

CN105943208B|2007-06-25|2019-02-15|微仙美国有限公司|Self-expanding prosthesis|

US8858490B2|2007-07-18|2014-10-14|Silk Road Medical, Inc.|Systems and methods for treating a carotid artery|

WO2009012473A2|2007-07-18|2009-01-22|Silk Road Medical, Inc.|Methods and systems for establishing retrograde carotid arterial blood flow|

US20090163945A1|2007-12-20|2009-06-25|Boston Scientific Scimed, Inc.|Polymeric slotted tube coils|

ES2821762T3|2008-02-05|2021-04-27|Silk Road Medical Inc|Interventional catheter system|

US20090227976A1|2008-03-05|2009-09-10|Calabria Marie F|Multiple biocompatible polymeric strand aneurysm embolization system and method|

CN106798586B|2008-04-21|2020-06-19|科维蒂恩有限合伙公司|Braided ball embolization device and delivery system|

WO2009132141A1|2008-04-22|2009-10-29|Coherex Medical, Inc.|Device, system and method for aneurysm embolization|

JP2011519300A|2008-05-01|2011-07-07|アニュクローズエルエルシー|Aneurysm occlusion device|

AU2009274126A1|2008-07-22|2010-01-28|Covidien Lp|Vascular remodeling device|

EP2323566A2|2008-08-13|2011-05-25|Silk Road Medical, Inc.|Suture delivery device|

US8574245B2|2008-08-13|2013-11-05|Silk Road Medical, Inc.|Suture delivery device|

US8246876B2|2008-08-18|2012-08-21|Cook Medical Technologies Llc|Embolization particles and method for making same|

KR101643371B1|2008-08-19|2016-07-27|마이크로 테라퓨틱스 인코포레이티드|Detachable tip microcatheter|

US20110212179A1|2008-10-30|2011-09-01|David Liu|Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same|

US20100131002A1|2008-11-24|2010-05-27|Connor Robert A|Stent with a net layer to embolize and aneurysm|

US8992506B2|2008-12-10|2015-03-31|MircoVention, Inc.|Microcatheter|

US8808303B2|2009-02-24|2014-08-19|Microport Orthopedics Holdings Inc.|Orthopedic surgical guide|

US9017334B2|2009-02-24|2015-04-28|Microport Orthopedics Holdings Inc.|Patient specific surgical guide locator and mount|

US8808297B2|2009-02-24|2014-08-19|Microport Orthopedics Holdings Inc.|Orthopedic surgical guide|

US8483863B1|2009-05-12|2013-07-09|Glenn Knox|Surgical bone and cartilage shaping on demand with 3D CAD/CAM|

CA2771317A1|2009-08-19|2011-02-24|Smith & Nephew, Inc.|Porous implant structures|

US10420862B2|2009-08-24|2019-09-24|Aresenal AAA, LLC.|In-situ forming foams for treatment of aneurysms|

US9173817B2|2009-08-24|2015-11-03|Arsenal Medical, Inc.|In situ forming hemostatic foam implants|

US9044580B2|2009-08-24|2015-06-02|Arsenal Medical, Inc.|In-situ forming foams with outer layer|

US20110087273A1|2009-10-08|2011-04-14|Tyco Healthcare Group Lp|Wound Closure Device|

US20110087274A1|2009-10-08|2011-04-14|Tyco Healtcare Group LP, New Haven, Ct|Wound Closure Device|

CA2779483C|2009-11-09|2018-03-13|Nfocus Neuromedical, Inc.|Braid ball embolic device features|

BR112012012860A2|2009-11-30|2017-04-04|Synthes Gmbh|expandable implant|

US8906057B2|2010-01-04|2014-12-09|Aneuclose Llc|Aneurysm embolization by rotational accumulation of mass|

US9468442B2|2010-01-28|2016-10-18|Covidien Lp|Vascular remodeling device|

EP2528541B1|2010-01-28|2016-05-18|Covidien LP|Vascular remodeling device|

US8425548B2|2010-07-01|2013-04-23|Aneaclose LLC|Occluding member expansion and then stent expansion for aneurysm treatment|

CN102100930B|2010-08-27|2014-05-21|上海微创医疗器械（集团）有限公司|Embolic agent and preparation method thereof|

AU2012214240B2|2011-02-11|2015-03-12|Covidien Lp|Two-stage deployment aneurysm embolization devices|

AU2012222114B2|2011-02-25|2016-06-16|Microvention, Inc.|Reinforced balloon catheter|

US10028745B2|2011-03-30|2018-07-24|Noha, Llc|Advanced endovascular clip and method of using same|

CA2835427A1|2011-05-11|2012-11-15|Microvention, Inc.|Device for occluding a lumen|

US9138232B2|2011-05-24|2015-09-22|Aneuclose Llc|Aneurysm occlusion by rotational dispensation of mass|

US8993831B2|2011-11-01|2015-03-31|Arsenal Medical, Inc.|Foam and delivery system for treatment of postpartum hemorrhage|

US20130289690A1|2011-11-01|2013-10-31|Hira V. Thapliyal|Personalized prosthesis and methods of use|

EP3342354B1|2011-11-08|2021-03-03|Boston Scientific Scimed, Inc.|Handle assembly for a left atrial appendage occlusion device|

US9579104B2|2011-11-30|2017-02-28|Covidien Lp|Positioning and detaching implants|

US8758427B2|2011-12-02|2014-06-24|Vascular Solutions, Inc.|Elongated expandable member for occluding varicose veins|

US9687245B2|2012-03-23|2017-06-27|Covidien Lp|Occlusive devices and methods of use|

EP2833837A4|2012-04-06|2015-11-25|Merlin Md Pte Ltd|Devices and methods for treating an aneurysm|

US10124087B2|2012-06-19|2018-11-13|Covidien Lp|Detachable coupling for catheter|

US9155647B2|2012-07-18|2015-10-13|Covidien Lp|Methods and apparatus for luminal stenting|

WO2014025930A1|2012-08-09|2014-02-13|Silk Road Medical, Inc.|Suture delivery device|

US9186267B2|2012-10-31|2015-11-17|Covidien Lp|Wing bifurcation reconstruction device|

US9314248B2|2012-11-06|2016-04-19|Covidien Lp|Multi-pivot thrombectomy device|

US20140135811A1|2012-11-13|2014-05-15|Covidien Lp|Occlusive devices|

US9295571B2|2013-01-17|2016-03-29|Covidien Lp|Methods and apparatus for luminal stenting|

US9662119B2|2013-03-13|2017-05-30|Lawrence Livermore National Security, Llc|Shape-memory polymer foam device for treating aneurysms|

US9463105B2|2013-03-14|2016-10-11|Covidien Lp|Methods and apparatus for luminal stenting|

CN103330583B|2013-06-05|2015-01-28|东南大学|Embolism intervention catheter and application thereof|

US20150007827A1|2013-07-02|2015-01-08|Conceptus, Inc.|Occlusion device with openable channel|

US9730701B2|2014-01-16|2017-08-15|Boston Scientific Scimed, Inc.|Retrieval wire centering device|

EP3113722A4|2014-03-07|2017-12-06|Endologix, Inc.|Forming hydrogels and materials therefor|

WO2015175537A1|2014-05-16|2015-11-19|Silk Road Medical, Inc.|Vessel access and closure assist system and method|

US10643371B2|2014-08-11|2020-05-05|Covidien Lp|Treatment procedure planning system and method|

US9375333B1|2015-03-06|2016-06-28|Covidien Lp|Implantable device detachment systems and associated devices and methods|

US9943314B2|2015-04-14|2018-04-17|Teleflex Innovations S.À.R.L.|Magnetically-driven delivery assembly and method|

CN107530161A|2015-04-22|2018-01-02|艾纽梅德公司|Personalized prosthese and dispositions method|

US10307168B2|2015-08-07|2019-06-04|Terumo Corporation|Complex coil and manufacturing techniques|

US10959761B2|2015-09-18|2021-03-30|Ortho-Space Ltd.|Intramedullary fixated subacromial spacers|

EP3373829A1|2015-11-13|2018-09-19|Cardiac Pacemakers, Inc.|Bioabsorbable left atrial appendage closure with endothelialization promoting surface|

TR201606296A1|2016-05-12|2017-11-21|Invamed Saglik Ilac Sanayi Ve Ticaret Anonim Sirketi|AN EMBOLIZATION AGENT FOR VARICOSITY AND / OR HEMOROID CLOSING|

AU2017204355B2|2016-07-08|2021-09-09|Mako Surgical Corp.|Scaffold for alloprosthetic composite implant|

CN106620874A|2017-01-10|2017-05-10|首都医科大学附属北京友谊医院|Method for preparing artificial blood vessel and artificial blood vessel|

CN108338816B|2017-01-22|2020-06-26|北京市神经外科研究所|Use of stent releasers or their combination with medical guide wires in the treatment of electro-thrombosis|

CN108338817B|2017-01-22|2020-06-26|北京市神经外科研究所|Use of guide wires in electro-thrombosis treatment|

CN108339195B|2017-01-22|2020-06-26|北京市神经外科研究所|Device and method for forming electric thrombus|

US11045981B2|2017-01-30|2021-06-29|Ortho-Space Ltd.|Processing machine and methods for processing dip-molded articles|

US11219520B2|2017-03-14|2022-01-11|Shape Memory Medical, Inc.|Shape memory polymer foams to seal space around valves|

US10485903B2|2017-12-21|2019-11-26|Shape Memory Medical, Inc.|Vascular prosthesis for leak prevention during endovascular aneurysm repair|

DE102019206493A1|2019-05-06|2020-11-12|Rheinisch-Westfälische Technische HochschuleAachen|Endovascular vascular graft and process for its manufacture|

法律状态:
2002-12-12| STCF| Information on status: patent grant|Free format text: PATENTED CASE |

2003-02-18| CC| Certificate of correction|

2006-06-23| FPAY| Fee payment|Year of fee payment: 4 |

2010-06-28| FPAY| Fee payment|Year of fee payment: 8 |

2010-06-29| SULP| Surcharge for late payment|

2014-06-30| FPAY| Fee payment|Year of fee payment: 12 |

优先权:

申请号 | 申请日 | 专利标题

US09/110,816|US6165193A|1998-07-06|1998-07-06|Vascular embolization with an expansible implant|

US09/730,071|US6500190B2|1998-07-06|2000-12-05|Vascular embolization with an expansible implant|US09/730,071| US6500190B2|1998-07-06|2000-12-05|Vascular embolization with an expansible implant|

US10/309,442| US7029487B2|1998-07-06|2002-12-04|Vascular embolization with an expansible implant|

US10/320,033| US7201762B2|1998-07-06|2002-12-16|Vascular embolization with an expansible implant|

US11/733,697| US7483558B2|1998-07-06|2007-04-10|Vascular embolization with an expansible implant|

US12/337,520| US7799047B2|1998-07-06|2008-12-17|Vascular embolization with an expansible implant|

US12/877,906| US9034005B2|1998-07-06|2010-09-08|Vascular embolization with an expansible implant|

[返回顶部]